Ethyl pyruvate attenuates delayed experimental cerebral vasospasm following subarachnoid haemorrhage in rats: possible role of JNK pathway
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منابع مشابه
Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm.
Despite improvements in the clinical management of aneurysmal subarachnoid haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single most important cause of morbidity and mortality in those patients who survive the initial bleed. The pathological mechanisms underlying DCI are still unclear and the calcium channel blocker nimodipine remains the only therapeutic interv...
متن کاملMagnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats.
We induced experimental delayed cerebral vasospasm by the intracisternal injection of greater than 0.5 ml blood in 30 rats. Seventy-two hours later the basilar artery was exposed via the transclival approach and photographed at high-power magnification through an operating microscope. We then evaluated the effect of topical (n = 30) and intravenous (n = 20) magnesium sulfate on the spastic arte...
متن کاملUltrastructure of cerebral arteries following experimental subarachnoid haemorrhage.
Scanning and transmission electron microscopy have been used to examine the ultrastructure of cerebral arteries taken from dogs up to nine days following the injection of autologous blood into the suprachiasmatic cistern and using meticulous perfusion-fixation technique. No ultrastructural changes in the cerebral arteries were noted either at sites of radiologically demonstrated arterial constr...
متن کاملcerebral vasospasm following traumatic subarachnoid hemorrhage
background: cerebral vasospasm is a preventable cause of death and disability in patients who experience aneurysmal subarachnoid hemorrhage (sah). the aim of this study is to investigate the incidence of cerebral vasospasm following traumatic sah and its relationship with different brain injuries and severity of trauma. method s: this cross-sectional study was conducted from october 2006 to mar...
متن کاملEffect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.
The effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH) was investigated in a rat model. Seven groups of seven rats underwent no SAH, no treatment; SAH only; SAH plus vehicle; SAH plus 3 days intraperitoneal raloxifene treatment; SAH plus 4 days intraperitoneal raloxifene treatment; SAH plus 3 days intrathecal raloxifene treatment; and SAH plus 4 days...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c7ra10801j